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Product Name
Anti-Tryptophan Hydroxylase 1/TPH1 antibody
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Description
Rabbit monoclonal to Tryptophan Hydroxylase 1/TPH1
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Tested applications
WB, IP
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Species reactivity
Human Tryptophan Hydroxylase 1 / TPH1
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Alternative names
MGC119994 antibody; Tph antibody; TPH1 antibody; TPH1 antibody; TPRH antibody; TRPH antibody; Tryptophan Hydroxylase 1 antibody; Tryptophan Hydroxylase 1 antibody; TPRH antibody; TRPH antibody; Tph antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Tryptophan Hydroxylase 1 / TPH1 (rh Tryptophan Hydroxylase 1 / TPH1; P17752-1; Ile2-Ile444).
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Clonality
Monoclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 5-10 μg/ml
IP: 1-4 uL/mg of lysate
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Validations
Tryptophan Hydroxylase 1 / TPH1 Antibody, Rabbit MAb, Western blot
Tryptophan Hydroxylase 1 / TPH1 Antibody, Rabbit MAb
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Background
Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme which belongs to the biopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains one ACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. TPH1 expression is limited to a few specialized tissues: raphe neurons, pinealocytes, mast cells, mononuclear leukocytes, beta-cells of the islets of Langerhans, and intestinal and pancreatic enterochromaffin cells.The tryptophan hydroxylase 1 (TPH1) gene is also reported to be associated with suicidal behavior. Polymorphisms of TPH1 may assist in identifying a subgroup of mood disorder patients that is at higher risk for suicidal behavior.
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References
- Antonia S. New, et al.,1998, American Journal of Medical Genetics Part B. 81 (1): 13-17.
- Y. C Wang, et al.,2001, Neuropsychobiology. 43 (1): 1 - 4.
- Diego J. et al., 2003, Science. 299 (5603): 76.
- Allen NC, et al.,2008, Nat Genet. 40 (7): 827-34.
- Galfalvy,H. et al., 2009, J Affect Disord. 115 (3):331-8.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"