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Product Name
TPH1 antibody
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Description
TPH1 Rabbit Polyclonal antibody. Positive WB detected in SH-SY5Y cells. Observed molecular weight by Western-blot: 51 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
TPH antibody; TPH1 antibody; TPRH antibody; TRPH antibody; Tryptophan 5 hydroxylase 1 antibody; Tryptophan 5 monooxygenase 1 antibody; tryptophan hydroxylase 1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TPH1 recombinant protein (Accession Number: NM_004179). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
SH-SY5Y cells were subjected to SDS PAGE followed by western blot with Catalog No:116263(TPH1 Antibody) at dilution of 1:300
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Background
Tryptophan hydroxylase 1(TPH1) catalyzes the rate-limiting step in the synthesis of serotonin in the periphery. Recently, it has been shown that expression of the tryptophan hydroxylase 1 gene is increased in lungs and pulmonary endothelial cells from patients with idiopathic pulmonary arterial hypertension. It catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. The protein has low expression.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"