TPH1 antibody

Cat.#: 116263

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Product Information

  • Product Name
    TPH1 antibody
  • Documents
  • Description
    TPH1 Rabbit Polyclonal antibody. Positive WB detected in SH-SY5Y cells. Observed molecular weight by Western-blot: 51 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    TPH antibody; TPH1 antibody; TPRH antibody; TRPH antibody; Tryptophan 5 hydroxylase 1 antibody; Tryptophan 5 monooxygenase 1 antibody; tryptophan hydroxylase 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of TPH1 recombinant protein (Accession Number: NM_004179). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

  • Validations

    SH-SY5Y cells were subjected to SDS PAGE followed by western blot with Catalog No:116263(TPH1 Antibody) at dilution of 1:300

    SH-SY5Y cells were subjected to SDS PAGE followed by western blot with Catalog No:116263(TPH1 Antibody) at dilution of 1:300

  • Background
    Tryptophan hydroxylase 1(TPH1) catalyzes the rate-limiting step in the synthesis of serotonin in the periphery. Recently, it has been shown that expression of the tryptophan hydroxylase 1 gene is increased in lungs and pulmonary endothelial cells from patients with idiopathic pulmonary arterial hypertension. It catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. The protein has low expression.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"