TRPV4 antibody

TRPV4 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TRPV4 Rabbit Polyclonal antibody. Positive IHC detected in human kidney tissue, human testis tissue. Positive WB detected in SH-SY5Y cells, Y79 cells. Observed molecular weight by Western-blot: 85-98 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

Osm 9 like TRP channel 4 antibody; OTRPC4 antibody; TRP12 antibody; TRPV4 antibody; VR OAC antibody; VRL 2 antibody; VRL2 antibody; VROAC antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_021625). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

TRPV4, also named as VRL2 and VROAC, belongs to the transient receptor family and TrpV subfamily. It is a non-selective calcium permeant cation channel protein which involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. It is activated by low pH, citrate and phorbol esters. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3). Defects in TRPV4 are the cause of spondylometaphyseal dysplasia Kozlowski type (SMDK). Defects in TRPV4 are the cause of metatropic dysplasia (MTD). The antibody is specific to TRPV4.