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TRPC1 antibody

Cat.#: 116405

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Product Information

  • Product Name
    TRPC1 antibody
  • Documents
  • Description
    TRPC1 Rabbit Polyclonal antibody. Positive IF detected in PC-12 cells. Positive FC detected in PC-3 cells. Positive WB detected in PC-3 cells, human brain tissue, human testis tissue, mouse liver tissue, SH-SY5Y cells. Observed molecular weight by Western-blot: 90 kDa,130 kDa
  • Tested applications
    ELISA, WB, IF, FC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    HTRP 1 antibody; Transient receptor protein 1 antibody; TRP 1 antibody; TRP1 antibody; TRPC1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_003304). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IF: 1:10-1:100

  • Validations

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:116405(TRPC1 antibody) at dilution of 1:500

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:116405(TRPC1 antibody) at dilution of 1:500

    Immunofluorescent analysis of PC-12 cells using Catalog No:116405(TRPC1 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of PC-12 cells using Catalog No:116405(TRPC1 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    1X10^6 PC-3 cells were stained with 0.2ug TRPC1 antibody (Catalog No:116405, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.

    1X10^6 PC-3 cells were stained with 0.2ug TRPC1 antibody (Catalog No:116405, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.

  • Background
    TRPC1, also named as TRP1, belongs to the transient receptor family and STrpC subfamily. TRPC1 is thought to form a receptor-activated non-selective calcium permeant cation channel. It has been reported that the mGluR1 evoked slow EPSC is mediated by the TRPC1 cation channel. It is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors.
  • References
    • Schmid E, Bhandaru M, Nurbaeva MK. SGK3 regulates Ca(2+) entry and migration of dendritic cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 30(6):1423-35. 2012.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"