Cart 2

TNNC1 antibody

Cat.#: 116148

Size:

Special Price 239.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    TNNC1 antibody
  • Documents
  • Description
    TNNC1 Rabbit Polyclonal antibody. Positive WB detected in human stomach tissue. Positive IHC detected in human heart tissue, human lung tissue. Observed molecular weight by Western-blot: 18 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    CMD1Z antibody; TN C antibody; TNC antibody; TNNC antibody; TNNC1 antibody; troponin C type 1 (slow) antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of TNNC1 recombinant protein (Accession Number: NM_003280). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    human stomach tissue were subjected to SDS PAGE followed by western blot with Catalog No:116148(TNNC1 antibody) at dilution of 1:500

    human stomach tissue were subjected to SDS PAGE followed by western blot with Catalog No:116148(TNNC1 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human heart using Catalog No:116148(TNNC1 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human heart using Catalog No:116148(TNNC1 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human heart using Catalog No:116148(TNNC1 antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human heart using Catalog No:116148(TNNC1 antibody) at dilution of 1:50 (under 40x lens)

  • Background
    Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. TnC plays an important role in excitation-contraction coupling and is the primary target of compounds such as levosimendan that augment Ca2+ responsiveness of the thin filament.
  • References
    • Leung CS, Yeung TL, Yip KP. Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential. Nature communications. 5:5092. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"