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Product Name
TMEM70 antibody
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Description
TMEM70 Mouse Monoclonal antibody. Positive IHC detected in human liver tissue, human pancreas tissue. Positive WB detected in A2780 cells. Observed molecular weight by Western-blot: 18 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse; other species not tested.
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Alternative names
FLJ20533 antibody; TMEM70 antibody; transmembrane protein 70 antibody
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Isotype
Mouse IgG2b
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Preparation
This antibody was obtained by immunization of TMEM70 recombinant protein (Accession Number: NM_017866). Purification method: Protein A purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
A2780 cells were subjected to SDS PAGE followed by western blot with Catalog No:107628(TMEM70 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human liver using Catalog No:107628(TMEM70 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver using Catalog No:107628(TMEM70 antibody) at dilution of 1:50 (under 40x lens)
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Background
TMEM70 belongs to the TMEM70 family. It is involved in biogenesis of mitochondrial ATP synthase. Defects in TMEM70 are a cause of mitochondrial encephalocardiomyopathy neonatal due to ATP synthase deficiency (MT-ATPSD). A publication (PMID:21147908) identified TMEM70 gene defect as a pan-ethnic disorder and further redefined it as the most common cause of nuclear-origin ATP synthase deficiency.
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References
- Kratochvílová H, Hejzlarová K, Vrbacký M. Mitochondrial membrane assembly of TMEM70 protein. Mitochondrion. 15:1-9. 2014.
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