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Product Name
Mouse Thrombopoietin/THPO (His Tag) recombinant protein
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Description
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
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Protein name
Thrombopoietin
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Protein short names
TPO-4; TPO; MKCSF; RP23-148P12.1; THCYT1; MGC163194; THROMBOPOIETIN; TPO-1; THPO; MGDF; TPO-3; TPO-2; ML; MPLLG
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Uniprot ID
Q543R9
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Gene Name
Thpo
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse THPO (NP_033405.1) precursor (Met 1-Thr 356) with a N-terminal polyhistidine tag was expressed.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse THPO consists of 346 amino acids with the predicted molecular mass of 37 kDa. As a result of glycosylation, rmTHPO migrates as an approximately 80-90 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells.
The ED50 for this effect is typically 0.5-2.5 ng/mL. -
Validations
Mouse Thrombopoietin / THPO / TPO Protein (His Tag) SDS-PAGE
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