Mouse Thrombopoietin/THPO (His Tag) recombinant protein

Cat.#: 502393

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Product Information

  • Product Name
    Mouse Thrombopoietin/THPO (His Tag) recombinant protein
  • Documents
  • Description
    Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
  • Protein name
    Thrombopoietin
  • Protein short names
    TPO-4; TPO; MKCSF; RP23-148P12.1; THCYT1; MGC163194; THROMBOPOIETIN; TPO-1; THPO; MGDF; TPO-3; TPO-2; ML; MPLLG
  • Uniprot ID
    Q543R9
  • Gene Name
    Thpo
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse THPO (NP_033405.1) precursor (Met 1-Thr 356) with a N-terminal polyhistidine tag was expressed.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse THPO consists of 346 amino acids with the predicted molecular mass of 37 kDa. As a result of glycosylation, rmTHPO migrates as an approximately 80-90 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Activity
    Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells.
    The ED50 for this effect is typically 0.5-2.5 ng/mL.
  • Validations

    Mouse Thrombopoietin / THPO / TPO Protein (His Tag) SDS-PAGE

    Mouse Thrombopoietin / THPO / TPO Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"