TCF7L1 antibody

Cat.#: 115907

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Product Information

  • Product Name
    TCF7L1 antibody
  • Documents
  • Description
    TCF7L1 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 63kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    human, mouse, rat; other species not tested.
  • Alternative names
    TCF7L1 antibody; Transcription factor 7 like 1 antibody; TCF3 antibody; TCF 3 antibody; HMG box transcription factor 3 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of TCF7L1 recombinant protein (Accession Number: NM_031283). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:115907(TCF7L1 antibody) at dilution of 1:1000

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:115907(TCF7L1 antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115907(TCF7L1 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115907(TCF7L1 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115907(TCF7L1 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115907(TCF7L1 antibody) at dilution of 1:100 (under 40x lens)

  • Background
    TCF7L1 is one of TCF/LEF transcription factors that are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It's necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis
  • References
    • Meinhardt G, Haider S, Haslinger P. Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. Endocrinology. 155(5):1908-20. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"