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Product Name
TCF7L1 antibody
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Description
TCF7L1 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 63kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
TCF7L1 antibody; Transcription factor 7 like 1 antibody; TCF3 antibody; TCF 3 antibody; HMG box transcription factor 3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of TCF7L1 recombinant protein (Accession Number: NM_031283). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:115907(TCF7L1 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115907(TCF7L1 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115907(TCF7L1 antibody) at dilution of 1:100 (under 40x lens)
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Background
TCF7L1 is one of TCF/LEF transcription factors that are mediators of the Wnt signaling pathway and are antagonized by the TGF-beta signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It's necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis
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References
- Meinhardt G, Haider S, Haslinger P. Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. Endocrinology. 155(5):1908-20. 2014.
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