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Product Name
Mouse CD8a / Lyt2 (His Tag) recombinant protein
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Description
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
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Protein name
T-cell surface glycoprotein CD8 alpha chain
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Protein short names
LY-35; LYT-2; CD8; BB154331; CD8A; LY-B; LEU2; LY-2; MAL; P32
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Uniprot ID
P01731
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Gene Name
Cd8a; Lyt-2; Lyt2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain of mouse CD8a (NP_001074579.1) (Met 1-Tyr 196) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse CD8a consists of 180 amino acids and has a calculated molecular mass of 20.3 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 35 kDa protein in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Activity
1. Measured by its ability to bind biotinylated recombinant human B2M in a functional ELISA.
2. Measured by its ability to bind biotinylated recombinant human FCGRT+B2M in a functional ELISA.
3. Measured by its ability to bind biotinylated recombinant human LCK in a functional ELISA. -
Validations
Mouse CD8a / Lyt2 Protein (His Tag) SDS-PAGE
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