Human CD8A recombinant protein (C-His)

Human CD8A recombinant protein (C-His)

• DataSheet
• Material Safety Data Sheets (MSDS)

Human T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I  membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.

T-cell surface glycoprotein CD8 alpha chain

CD8,CD8 alpha,Leu-2,Leu2,MAL,p32,p32 186910

P01732

T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; CD antigen CD8a

Human Cells

A DNA sequence encoding the extracellular domain of human CD8A (NP_001759.3) (Met1-Asp182) was expressed with a C-terminal polyhistidine tag. The purified protein was biotinylated in vitro.

Human

The recombinant human CD8A consists of 172 amino acids and predicts a molecular mass of 19 kDa.

> 95 % as determined by SDS-PAGE