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  • SYNM antibody
  • SYNM antibody
  • SYNM antibody
  • SYNM antibody

SYNM antibody

Cat.#: 115786

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Special Price 239.0 USD

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Product Information

  • Product Name
    SYNM antibody
  • Documents
  • Description
    SYNM Rabbit Polyclonal antibody. Positive IF detected in HeLa cells. Positive IHC detected in human skeletal muscle tissue, human bladder tissue, human heart tissue. Positive WB detected in Y79 cells, human skeletal muscle tissue, Jurkat cells. Observed molecular weight by Western-blot: 170-180kd
  • Tested applications
    ELISA, WB, IHC, IF
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    Desmuslin antibody; DMN antibody; KIAA0353 antibody; SYN antibody; Synemin antibody; SYNM antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_015286). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

    IF: 1:10-1:100

  • Validations

    Y79 cells were subjected to SDS PAGE followed by western blot with Catalog No:115786(SYNM antibody) at dilution of 1:1000

    Y79 cells were subjected to SDS PAGE followed by western blot with Catalog No:115786(SYNM antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human skeletal muscle using Catalog No:115786(SYNM antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human skeletal muscle using Catalog No:115786(SYNM antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human skeletal muscle using Catalog No:115786(SYNM antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human skeletal muscle using Catalog No:115786(SYNM antibody) at dilution of 1:50 (under 40x lens)

    Immunofluorescent analysis of HeLa cells using Catalog No:115786(SYNM Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG

    Immunofluorescent analysis of HeLa cells using Catalog No:115786(SYNM Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG

  • Background
    SYNM, also named as DMN, KIAA0353 and SYN, belongs to the intermediate filament family. SYNM is a Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. The antibody can’t recognize isofor2 and 3 of SYNM.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"