SURVIVIN-Specific antibody

SURVIVIN-Specific antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SURVIVIN-Specific Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue, human colon cancer tissue, human lung cancer tissue, human pancreas cancer tissue. Positive IF detected in HeLa cells.

ELISA, IHC, IF

Human,Mouse,Rat; other species not tested.

API4 antibody; Apoptosis inhibitor 4 antibody; Apoptosis inhibitor survivin antibody; BIRC5 antibody; EPR 1 antibody; IAP4 antibody; SURVIVIN antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_001168). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

BIRC5, also named as API4 and IAP4, is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.BIRC5 may play a role in neoplasia and counteract a default induction of apoptosis in G2/M phase. The antibody can recognize all these isoforms of BIRC5.