Human SOCS3 (His & Trx Tag) recombinant protein

Human SOCS3 (His & Trx Tag) recombinant protein

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SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Suppressor of cytokine signaling 3

SOCS3; SSI-3; EF10; EF-10; CISH3; SSI3; CIS-3; SOCS-3; RP23-268N22.6; CIS3; ATOD4; MGC71791

O14543

SOCS3; CIS3; SSI3

E. coli

A DNA sequence encoding the human SOCS3 (O14543) (Met 1-Leu 225) was fused with a Trx and a polyhistide tag at the N-terminus.

Human

The recombinant human SOCS3/Trx fusion protein consisting of 384 amino acids and has a calculated molecular mass of 41.9 kDa. It migrates as an approximately 46 kDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE