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  • SUMO1 antibody

SUMO1 antibody

Cat.#: 115836

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Product Information

  • Product Name
    SUMO1 antibody
  • Documents
  • Description
    SUMO1 Rabbit Polyclonal antibody. Positive WB detected in NIH/3T3 cells, mouse spleen tissue. Observed molecular weight by Western-blot: 10-12 kDa,80-90 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    DAP 1 antibody; GAP modifying protein 1 antibody; GMP1 antibody; OFC10 antibody; PIC1 antibody; SENP2 antibody; Sentrin antibody; SMT3 antibody; SMT3 homolog 3 antibody; SMT3C antibody; SMT3H3 antibody; SUMO 1 antibody; SUMO1 antibody; Ubiquitin like protein SMT3C antibody; Ubiquitin like protein UBL1 antibody; UBL1 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of SUMO1 recombinant protein (Accession Number: BC006462). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

  • Validations

    NIH/3T3 cells were subjected to SDS PAGE followed by western blot with Catalog No:115836(SUMO1 antibody) at dilution of 1:600

    NIH/3T3 cells were subjected to SDS PAGE followed by western blot with Catalog No:115836(SUMO1 antibody) at dilution of 1:600

  • Background
    Ubiquitin is most famous for its function in targeting proteins for degradation by the 26S proteasome, ubiquitin needs to be attached to a substrate in chains (polyubiquitylation) before being recognized by proteasome. Similarly, SUMO (small ubiquitin-related modifier) can be linked to substrates in chains (polysumoylation), SUMO modification has been implicated in many important cellular processes including the control of genome stability, signal transduction, targeting to and formation of nuclear compartments, cell cycle and meiosis. There are 4 confirmed SUMO isoforms in human, SUMO-1, SUMO-2, SUMO-3 and SUMO-4. SUMO-2 and SUMO-3 are nearly identical but are distinct from SUMO-1. SUMO2/3 conjugation was recently widely involved in neuroprotective activities. A substitution (M55V) of SUMO4 was strongly associated with the pathogenesis of type 1 diabetes (T1D) involving NF kappa B related mechanisms.This antibody can detect endogenous levels of SUMOylated proteins (e.g. SUMO-1-RanGAP at 80-90 kD).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"