STMN4 antibody

STMN4 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

STMN4 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in human brain tissue. Positive IHC detected in human gliomas tissue, human brain tissue. Observed molecular weight by Western-blot: 25kd

ELISA, WB, IP, IHC

Human,Mouse,Rat; other species not tested.

RB3 antibody; Stathmin 4 antibody; stathmin like 4 antibody; Stathmin like protein B3 antibody; STMN4 antibody

Rabbit IgG

This antibody was obtained by immunization of STMN4 recombinant protein (Accession Number: NM_030795). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.