STAT5A antibody

STAT5A antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

STAT5A Rabbit Polyclonal antibody. Positive WB detected in NIH/3T3 cells, HeLa cells, HepG2 cells. Positive IHC detected in human cervical cancer tissue, human breast cancer tissue, human lung cancer tissue. Observed molecular weight by Western-blot: 92kd

ELISA, WB, IHC

Human, Mouse; other species not tested.

MGF antibody; STAT5 antibody; STAT5A antibody; STAT5A-Specific antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_003152). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

STAT5A, also named as STAT5, belongs to the transcription factor STAT family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5A is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of STAT5A in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of human STAT5A is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of STAT5A in cells. This antibody is specific to STAT5A. It has no cross reaction to STAT5B.