STAT2 antibody

STAT2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

STAT2 Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells, HT-1080 cells, K-562 cells. Positive IHC detected in human breast cancer tissue, human lung cancer tissue. Observed molecular weight by Western-blot: 113 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

ISGF 3 antibody; P113 antibody; STAT113 antibody; STAT2 antibody

Rabbit IgG

This antibody was obtained by immunization of STAT2 recombinant protein (Accession Number: NM_005419). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

STAT2, also named as p113, belongs to the transcription factor STAT family. It is a signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. It also interacts with CRSP2, CRSP6, Simian virus 5 protein V, rabies virus phosphoprotein, IFNAR1 and IFNAR2. Its interaction with dengue virus NS5 inhibits the phosphorylation of STAT2, and, when all viral proteins are present (polyprotein), STAT2 is targeted for degradation. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human STAT2.