-
Product Name
SPPL2A antibody
- Documents
-
Description
SPPL2A Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue, human kidney tissue. Positive WB detected in human colon tissue, Jurkat cells, mouse colon tissue. Observed molecular weight by Western-blot: 58kd
-
Tested applications
ELISA, WB, IHC
-
Species reactivity
Human,Mouse,Rat; other species not tested.
-
Alternative names
IMP 3 antibody; IMP3 antibody; Intramembrane protease 3 antibody; Presenilin like protein 2 antibody; PSL2 antibody; SPP like 2A antibody; SPPL2A antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of SPPL2A recombinant protein (Accession Number: NM_032802). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
-
Validations
human colon tissue were subjected to SDS PAGE followed by western blot with Catalog No:115640(SPPL2A antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human testis using Catalog No:115640(SPPL2A antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human testis using Catalog No:115640(SPPL2A antibody) at dilution of 1:50 (under 40x lens)
-
Background
SPPL2A(Signal peptide peptidase-like 2A) is also named as IMP3(Intramembrane protease 3), PSL2(Presenilin-like protein 2) and belongs to the peptidase A22B family. It is an aspartyl intramembrane protease, has been implicated in the proteolysis of TNF-alpha, Fas Ligand and Bri2 and endogenous signal-peptide-peptidase-like2A (SPPL2a) is localised in lysosomes/late endosomes(PMID:21896273). This protein has a signal peptide with 25 amino acid and seven glycosylation sites.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"