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Product Name
Human SMPD1 (His Tag) recombinant protein
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Description
Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.
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Protein name
Sphingomyelin phosphodiesterase
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Protein short names
ASM; ASMASE; ZN-SMASE; SMPD1; A-SMASE; NPD
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Uniprot ID
Q59EN6
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Gene Name
SMPD1; ASM
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human SMPD1 isoform 1 (NP_000534.3) (Gly 85-Cys 631) was expressed, fused with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The secreted recombinant human SMPD1 consists of 563 amino acids and predicts a molecular mass of 65 kDa as estimated by SDS-PAGE under reducing conditions.
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Purity
> 91 % as determined by SDS-PAGE
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Activity
Measured by its ability to cleave 2-N-Hexadecanoylamino-4-nitrophenylphosphorylcholine (HNPPC). The specific activity is 77 pmol/min/μg.
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Validations
Human SMPD1 / ASM Protein (His Tag) SDS-PAGE
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