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  • SOCS1 Polyclonal Antibody

SOCS1 Polyclonal Antibody

Cat.#: 160158

Special Price 290.3 USD

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Product Information

  • Product Name
    SOCS1 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to SOCS1
  • Tested applications
    WB, IHC, IF, FC
  • Species reactivity
    Mouse, Rat
  • Alternative names
    SOCS1 antibody; CIS1 antibody; CISH1 antibody; JAB antibody; SOCS-1 antibody; SSI-1 antibody; SSI1 antibody; TIP3 antibody; TIP-3 antibody; suppressor of cytokine signaling 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human SOCS1
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, pH7.3.
  • Storage instructions
    Store at 4℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
    IHC 1:50 - 1:200
    IF 1:20 - 1:50
    FC 1:20 - 1:50
  • Validations

    Western blot - SOCS1 Polyclonal Antibody

    Western blot - SOCS1 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using SOCS1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 90s.

  • Background
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"