SLIT2-Specific antibody

SLIT2-Specific antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SLIT2-Specific Rabbit Polyclonal antibody. Positive FC detected in HEK-293 cells. Positive IHC detected in human kidney tissue, human breast cancer tissue. Positive WB detected in HEK-293 cells, mouse brain tissue. Observed molecular weight by Western-blot: 130-140 kDa,200 kDa

ELISA, IHC, WB, FC

Human,Mouse,Rat; other species not tested.

FLJ14420 antibody; SLIL3 antibody; Slit 2 antibody; slit homolog 2 (Drosophila) antibody; Slit homolog 2 protein antibody; SLIT2 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_004787). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

SLIT2, also named as SLIL3, is thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development it is involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development, SLIT2 may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. SLIT2 may be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system it appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, it collapses and repels retinal ganglion cell growth cones. SLIT2 seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. It seems to be involved in regulating leukocyte migration. The antibody is specific to SLIT2.

• Gibson DA, Tymanskyj S, Yuan RC. Dendrite self-avoidance requires cell-autonomous slit/robo signaling in cerebellar purkinje cells. Neuron. 81(5):1040-56. 2014.