Mouse SLAMF8 (His Tag) recombinant protein

Mouse SLAMF8 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells. Mouse SLAM family member 8, also known as B-lymphocyte activator macrophage expressed, BCM-like membrane protein, SLAMF8 and BLAME, is a single-pass type I  membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

SLAM family member 8

SLAMF8; MGC129578; RP11-190A12.3; FLJ20442; SBBI42; BLAME; 5830408F06RIK; CD353

Q9D3G2

Slamf8

Human Cells

A DNA sequence encoding the mouse SLAMF8 (NP_083360.2) extracellular domain (Met 1-Asp 231) was fused with the a polyhistidine tag at the C-terminus.

Mouse

The secreted recombinant mouse SLAMF8 consists of 222 amino acids and has a predicted molecular mass of 24.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmSLAMF8 is approximately 33-38 kDa due to glycosylation.

> 80 % as determined by SDS-PAGE

Measured by its ability to bind biotinylated mouse SLAMF8 in a functional ELISA.