Anti-SLAMF8 antibody

Anti-SLAMF8 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to SLAMF8

IHC-P

Mouse SLAMF8

BLAME antibody; CD353 antibody; SBBI42 antibody; Blame antibody; SBBI42 antibody; 5830408F06Rik antibody; 5830408F06Rik antibody; Blame antibody; BLAME antibody; FLJ20442 antibody; MGC129578 antibody; RP11-190A12.3 antibody; SBBI42 antibody; SBBI42 antibody; SLAMF8 antibody; SLAMF8 antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SLAMF8 (rM SLAMF8; NP_083360.2; Met1-Asp231).

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells. Mouse SLAM family member 8, also known as B-lymphocyte activator macrophage expressed, BCM-like membrane protein, SLAMF8 and BLAME, is a single-pass type I  membrane protein. It contains one Ig-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

• Kingsbury G.A., et al., 2001, J. Immunol. 166:5675-80.
• Zhang Z., et al., 2004, Protein Sci. 13: 2819-24.
• Veillette,A. et al., 2006, Nat Rev Immunol  6 (1): 56-66.
• Veillette,A. et al., 2006, Trends Immunol  27 (5): 228-34.
• Yan,Q. et al., 2007, Proc Natl Acad Sci. USA.104 (25):10583-8.