SIRT6 antibody

SIRT6 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SIRT6 Rabbit Polyclonal antibody. Positive IHC detected in human brain. Positive WB detected in human brain tissue, HeLa cells. Observed molecular weight by Western-blot: 45-50kd

ELISA, WB, IHC

human, mouse, rat; other species not tested.

SIRT6 antibody; SIR2 like protein 6 antibody; SIR2L6 antibody

Rabbit IgG

This antibody was obtained by immunization of SIRT6 recombinant protein (Accession Number: NM_001193285). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

SIRT6, also named as SIR2L6, belongs to the sirtuin family. SIRT6 is a member of a highly conserved family of NAD+-dependent deacetylases with various roles in metabolism, stress resistance, and life span. It has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. SIRT6 modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. SIRT6 may be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. It is required for genomic stability. And it is required for normal IGF1 serum levels and normal glucose homeostasis. It modulates cellular senescence and apoptosis. It regulates the production of TNF protein. SIRT6 acts as a histone deacetylase to directly repress multiple glycolytic genes. SIRT6 also functions as a corepressor of the transcription factor Hif1α. Loss of SIRT6 increases glycolysis and diminishes mitochondrial respiration. SIRT6 plays a key role in regulating glucose homeostasis.

• Sun H, Wu Y, Fu D, Liu Y, Huang C. SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-κB signaling pathway. Stem cells (Dayton, Ohio). 32(7):1943-55. 2014.
• Sun HL, Wu YR, Huang C, Wang JW, Fu DJ, Liu YC. The effect of SIRT6 on the odontoblastic potential of human dental pulp cells. Journal of endodontics. 40(3):393-8. 2014.