SIRT2 antibody

SIRT2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SIRT2 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in human brain tissue, mouse brain tissue, rat kidney tissue. Positive IHC detected in human heart tissue, human breast cancer tissue. Observed molecular weight by Western-blot: 37-45 kDa

ELISA, WB, IHC, IP

Human, Mouse, Rat; other species not tested.

SIR2 antibody; SIR2 like protein 2 antibody; SIR2L antibody; SIR2L2 antibody; SIRT2 antibody

Rabbit IgG

This antibody was obtained by immunization of SIRT2 recombinant protein (Accession Number: XM_006723111). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The silent information regulator(SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. SIR2 contains a 323 amino acid catalytic core domain with a NAD-binding domain and a large groove which is the likely site of catalysis. SIR2 is widely expressed, highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. This antibody is a rabbit polyclonal antibody raised against the N-terminal 352 residues of human SIR2 protein.