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Product Name
Human SH2D1A (His Tag) recombinant protein
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Description
Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
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Protein name
SH2 domain-containing protein 1A
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Protein short names
LYP; DSHP; XLPD; RP5-1052M9.3; XLP; XLPD1; SAP; IMD5; EBVS; MTCP1; SAP/SH2D1A; RP23-280E8.1; FLJ92177; FLJ18687; GM686
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Uniprot ID
O60880
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Gene Name
SH2D1A; DSHP; SAP
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human SH2D1A isoform 1 (NP_002342.1) (Pro 2-Lys 97) was expressed, with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SH2D1A consisting of 139 amino acids and has a calculated molecular mass of 15.6 kDa.It migrates as an approximately 14 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 94 % as determined by SDS-PAGE
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Activity
1. Measured by its ability to bind recombinant human SLAMF1 in a functional ELISA.
2. Measured by its ability to bind recombinant human SLAMF6 in a functional ELISA.
3. Measured by its ability to bind recombinant mouse SLAMF6 in a functional ELISA.
4. Measured by its ability to bind recombinant mouse CD84 in a functional ELISA. -
Validations
Human SH2D1A Protein (His Tag) SDS-PAGE
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