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Product Name
SDHC antibody
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Description
SDHC Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue. Positive WB detected in human liver tissue, HepG2 cells, MCF7 cells, mouse lung tissue. Observed molecular weight by Western-blot: 15kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CYB560 antibody; CYBL antibody; PGL3 antibody; QPs 1 antibody; QPS1 antibody; SDH3 antibody; SDHC antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SDHC recombinant protein (Accession Number: NM_003001). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:115033(SDHC antibody) at dilution of 1:400
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115033(SDHC antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human breast cancer using Catalog No:115033(SDHC antibody) at dilution of 1:100 (under 40x lens)
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Background
SDHC(Succinate dehydrogenase cytochrome b560 subunit, mitochondrial) is also named as CYB560, SDH3 and belongs to the cytochrome b560 family. It is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Defects in SDHC are the cause of paragangliomas type 3 (PGL3) and paraganglioma and gastric stromal sarcoma (PGGSS). It has a transit peptide of 29 amino acid and has 5 isoforms produced by alternative splicing.
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