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Product Name
SCN4B antibody
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Description
SCN4B Rabbit Polyclonal antibody. Positive IHC detected in human skeletal muscle tissue. Positive WB detected in mouse heart tissue, mouse brain tissue. Observed molecular weight by Western-blot: 28 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
SCN4B antibody; Sodium channel subunit beta 4 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_174934). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:115007(SCN4B antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using Catalog No:115007(SCN4B Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using Catalog No:115007(SCN4B Antibody) at dilution of 1:50 (under 40x lens)
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Background
Mammalian sodium channels are heterotrimers, composed of a central, pore-forming alpha subunit and two auxiliary beta subunits (PMID: 11486343). SCN4B (sodium channel subunit beta-4) is one of several sodium channel beta subunits, which modulate channel gating kinetics. SCN4B has an N-terminal signal peptide, a large extracellular domain predicted to form an Ig-like fold, a single transmembrane alpha helix, and a short cytoplasmic C terminus. Defects in SCN4B gene are a cause of long QT syndrome type 10 (LQT10).
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