SALL4 antibody

SALL4 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

SALL4 Rabbit Polyclonal antibody. Positive IP detected in HepG2 cells. Positive WB detected in HepG2 cells. Positive IHC detected in human testis tissue, human ovary tumor tissue. Observed molecular weight by Western-blot: 66-75kDa

ELISA, WB, IHC, IP

Human; other species not tested.

dJ1112F19.1 antibody; DRRS antibody; HSAL4 antibody; sal like 4 (Drosophila) antibody; Sal like protein 4 antibody; SALL4 antibody; Zinc finger protein SALL4 antibody; ZNF797 antibody

Rabbit IgG

This antibody was obtained by immunization of SALL4 recombinant protein (Accession Number: NM_020436). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

SALL4, also named as Sal-like protein 4 or Zinc finger protein 797, Contains 7 C2H2-type zinc fingers and belongs to the sal C2H2-type zinc-finger protein family. SALL4 is constitutively expressed in acute myeloid leukemia. The constitutive expression of SALL4in mice is sufficient to induce MDS-like symptoms and transformation to AML that is transplantable. SALL4 is able to bind beta
-catenin and activate the Wnt/beta
-catenin signaling pathway. Sequence analysis of the larger cDNA fragment isolated revealed a single, large open-reading frame, designated as SALL4A, that started from a strong consensus initiation sequence and was expected to encode 1053 amino acids. The other splicing variant of SALL4, designated SALL4B, lacked the region corresponding to amino acids 385 to 820 of the full-length SALL4A. The putative protein encoded by SALL4B cDNA was expected to consist of 617 amino acids.

• Lin Y, Liu AY, Fan C. MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1. Scientific reports. 5:9995. 2015.
• Hao L, Zhao Y, Wang Z. Expression and clinical significance of SALL4 and β-catenin in colorectal cancer. Journal of molecular histology. 2016.