SAIDRSMIRF-amide peptide

SAIDRSMIRF-amide peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

SAIDRSMIRF

H-Ser-Ala-Ile-Asp-Arg-Ser-Met-Ile-Arg-Phe-OH

10

96.2%

C₅₁H₈₆N₁₆O₁₅S

1194.62

Synthetic

Powder

The source of SAIDRSMIRF-amide is Bombyx mori. SAIDRSMIRF-amide belongs to FMRFamide related peptide. SAIDRSMIRF-amide is expressed in Only expressed in the CNS and predominantly in the thoracic ganglia. Strongest expression is seen in two pairs of large neurons in each thoracic ganglion. These neurons are ventrolateral neurosecretory cells 1 and 2, they project their axons through transverse nerves into the periphery where axons from the prothoracic ganglion innervate the prothoracic gland. The peptide has the modification: 10 Phe amide

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Yamanaka N., Zitnan D., Kim Y.J., Adams M.E., Hua Y.J., Suzuki Y., Suzuki M., Suzuki A., Satake H., Mizoguchi A., Asaoka K., Tanaka Y., Kataoka H.; Regulation of insect steroid hormone biosynthesis by innervating peptidergic neurons.; Proc. Natl. Acad. Sci. U.S.A. 103:8622-8627(2006).

Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.