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Product Name
S1PR1/EDG1 antibody
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Description
S1PR1/EDG1 Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, SH-SY5Y cells. Observed molecular weight by Western-blot: 45-50 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
CD363 antibody; CHEDG1 antibody; D1S3362 antibody; ECGF1 antibody; EDG 1 antibody; EDG1 antibody; FLJ58121 antibody; S1P receptor 1 antibody; S1P receptor Edg 1 antibody; S1P1 antibody; S1PR1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_001400). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:1000
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114968(S1PR1 antibody) at dilution of 1:200
IP Result of anti-S1PR1 (IP:Catalog No:114968, 4ug; Detection:Catalog No:114968 1:300) with mouse brain tissue lysate 2640ug.
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Background
S1PR1 (sphingosine-1-phosphate receptor 1), also known as as S1P1 or EDG1, is one of five G-protein-coupled receptors for sphingosine-1-phosphate (S1P), a biologically active metabolite of sphingolipid (PMID: 18787560). S1P1 and its receptors have important regulatory functions in normal physiology and disease processes, particularly involving the immune, central nervous, and cardiovascular systems (PMID: 21339489). S1PR1 is widely expressed on various cell types, including endothelial cells and lymphocytes (PMID: 14737169). S1P-S1PR1 plays a major role in lymphocyte egress and chemotaxis, cell proliferation and survival and tumor angiogenesis and metastasis (PMID: 21102457). The antibody is specific to S1PR1.
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References
- Tong S, Tian J, Wang H. H9N2 avian influenza infection altered expression pattern of sphiogosine-1-phosphate receptor 1 in BALB/c mice. Virology journal. 10:296. 2013.
- Pan HY, Yang H, Shao MY. Sphingosine-1-phosphate mediates AKT/ERK maintenance of dental pulp homoeostasis. International endodontic journal. 48(5):460-8. 2015.
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