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Product Name
S100A11 antibody
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Description
S100A11 Mouse Monoclonal antibody. Positive WB detected in HeLa cells, A431 cells, human lung tissue. Positive IHC detected in human skin. Observed molecular weight by Western-blot: 12 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
S100A11 antibody; MLN70 antibody; Calgizzarin antibody; MLN 70 antibody; S100C antibody
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Isotype
Mouse IgG1
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Preparation
This antibody was obtained by immunization of S100A11 recombinant protein (Accession Number: NM_005620). Purification method: Caprylic acid/ammonium sulfate precipitation.
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Clonality
Monoclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:107518(S100A11 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human skin using Catalog No:107518(S100A11 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human skin using Catalog No:107518(S100A11 antibody) at dilution of 1:50 (under 40x lens)
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Background
S100A11,also named as MLN 70, Calgizzarin and S100C, Belongs to the S-100 family. It facilitates the differentiation and the cornification of keratinocytes. The naming of S100A11 systematically arises from its membership of the S100 protein family, named after their solubility in 100% saturated ammonium sulfate solution. First discovered in 1989, S100A11 has since been proposed to have direct biological functions in an assortment of physiological processes such as endo- and exocytosis, regulation of enzyme activity, cell growth and regulation, apoptosis and inflammation.
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References
- Fan C, Fu Z, Su Q, Angelini DJ, Van Eyk J, Johns RA. S100A11 mediates hypoxia-induced mitogenic factor (HIMF)-induced smooth muscle cell migration, vesicular exocytosis, and nuclear activation. Molecular & cellular proteomics : MCP. 10(3):M110.000901. 2011.
- Weeraphan C, Diskul-Na-Ayudthaya P, Chiablaem K. Effective enrichment of cholangiocarcinoma secretomes using the hollow fiber bioreactor culture system. Talanta. 99:294-301. 2012.
- Lu Y, Guo J, Di Y, Zong Y, Qu S, Tian J. Proteomic analysis of the triglyceride-rich lipoprotein-laden foam cells. Molecules and cells. 28(3):175-81. 2009.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"