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Product Name
Anti-S100A11 / S100C antibody
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Description
Rabbit polyclonal to S100A11 / S100C
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Tested applications
ELISA, WB, IP
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Species reactivity
Human S100A11 / S100C
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Alternative names
CAL antibody; MLN 70 antibody; S100C antibody; EMAP antibody; Emap1 antibody; EMAPI antibody; MGC107585 antibody; MLN70 antibody; S100A11 antibody; S100A11 antibody; S100a14 antibody; S100c antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human S100A11 / S100C (rh S100A11 / S100C; NP_005611.1; Met1-Thr105). S100A11 / S100C specific IgG was purified by Human S100A11 / S100C affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 2-10 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human S100A11 / S100C. The detection limit for Human S100A11 / S100C is < 0.039 ng/well.
IP: 1-4 μg/mg of lysate
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Validations
S100A11 / S100C Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
S100A11 / S100C Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of the S-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell periphery. S100A11 exists as a non-covalent homodimer with an antiparallel conformation. Ca(2+) binding to S100A11 would trigger conformational changes which would expose the hydrophobic cleft of S100A11 and facilitate its interaction with target proteins. As a dual cell growth mediator, S100A11 acts as either a tumor suppressor or promoter in many different types of tumors and would play respective roles in influencing the proliferation of the cancer cells. In the nucleus, S100A11 suppresses the growth of keratinocytes through p21 (CIP1/WAF1) activation and induces cell differentiation. S100A11 is also a novel diagnostic marker in breast carcinoma.
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References
- Miyasaki KT. et al., 1993, J Dent Res. 72: 517-23.
- Ohuchida K. et al., 2006, Clin Cancer Res 12 (18): 5417-22.
- Kouno T. et al., 2008, J Pept Sci. 14 (10): 1129-38.
- He H. et al., 2009, Cell Biochem Biophys 55 (3): 117-26.
- Liu XG. et al., 2010, Oncol Rep. 23 (5): 1301-8.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"