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Product Name
RSPO2 antibody
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Description
RSPO2 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Positive IP detected in mouse brain tissue. Positive IHC detected in mouse small intestine tissue. Observed molecular weight by Western-blot: 33 kDa
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Tested applications
ELISA, WB, IP, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CRISTIN2 antibody; hRspo2 antibody; R spondin 2 antibody; Roof plate specific spondin 2 antibody; RSPO2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of RSPO2 recombinant protein (Accession Number: NM_001317942). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:1000-1:10000
IP: 1:200-1:2000
IHC: 1:50-1:500
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:114851(RSPO2 antibody) at dilution of 1:3000
IP Result of anti-RSPO2 (IP:Catalog No:114851, 4ug; Detection:Catalog No:114851 1:500) with mouse brain tissue lysate 2640ug.
Immunohistochemistry of paraffin-embedded mouse small intestine tissue slide using Catalog No:114851(RSPO2 Antibody) at dilution of 1:200 (under 10x lens).
Immunohistochemistry of paraffin-embedded mouse small intestine tissue slide using Catalog No:114851(RSPO2 Antibody) at dilution of 1:200 (under 40x lens).
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Background
RSPO2 is one of the R-spondins (RSPOs) which comprise a family of four secreted proteins that have important roles in cell proliferation, cell fate determination and organogenesis. RSPOs typically exert their effects by potentiating the Wnt/beta-catenin signaling pathway. Overexpression of Rspo2 is sufficient to promote bone morphogenetic protein-induced mineralization Rspo2 was identified as a novel common integration site (CIS) for the mouse mammary tumor virus (MMTV) in viral induced mouse mammary tumors.
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References
- Shinmura K, Kahyo T, Kato H. RSPO fusion transcripts in colorectal cancer in Japanese population. Molecular biology reports. 41(8):5375-84. 2014.
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