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Product Name
RRM1-Specific antibody
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Description
RRM1-Specific Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in A549 cells, HEK-293 cells, HeLa cells. Observed molecular weight by Western-blot: 80-90 kDa
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Tested applications
ELISA, WB, IF
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ribonucleotide reductase M1 antibody; RIR1 antibody; RR1 antibody; RRM1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_001033). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IF: 1:10-1:100
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Validations
A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:114924(RRM1-Specific antibody) at dilution of 1:100
Immunofluorescent analysis of HepG2 cells, using RRM1 antibody Catalog No:114924 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
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Background
RRM1, also named as RR1, belongs to the ribonucleoside diphosphate reductase large chain family. RRM1 provides the precursors necessary for DNA synthesis. RRM1 catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.RRM1 is a key enzyme in DNA synthesis: low level expression of RRM1 is associated with poor survival. RRM1 is a prognostic marker of NSCLC. The antibody is specfic to RRM1.
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