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Product Name
RPH3AL antibody
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Description
RPH3AL Rabbit Polyclonal antibody. Positive WB detected in human liver tissue, L02 cells. Positive IP detected in HepG2 cells. Observed molecular weight by Western-blot: 38kd
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Tested applications
ELISA, WB, IP
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Species reactivity
Human; other species not tested.
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Alternative names
No C2 domains protein antibody; NOC2 antibody; Rab effector NOC2 antibody; Rabphilin 3A like protein antibody; RPH3AL antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of RPH3AL recombinant protein (Accession Number: NM_001190412). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
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Validations
human liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:114807(Noc2 antibody) at dilution of 1:500
IP Result of anti-Noc2 (IP:Catalog No:114807, 4ug; Detection:Catalog No:114807 1:500) with HepG2 cells lysate 2400ug.
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Background
Rabphilin-3A-like (RPH3AL), also known as Noc2, is a Rab effector protein with a molecular weight of 38 kDa. It is expressed abundantly in endocrine cells but at low levels in exocrine tissues, playing a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells, and also having a key role in insulin secretion by pancreatic cells. RPH3AL functions as a potential RAB3B effector protein in epithelial cells, and RPH3AL gene is likely a tumor suppressor.
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References
- Chen JS, Kuo YB, Chou YP. Detection of autoantibodies against Rabphilin-3A-like protein as a potential biomarker in patient's sera of colorectal cancer. Clinica chimica acta; international journal of clinical chemistry. 412(15-16):1417-22. 2011.
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