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Product Name
RPH3A antibody
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Description
RPH3A Rabbit Polyclonal antibody. Positive IF detected in COLO 320 cells. Positive WB detected in COLO 320 cells, human brain tissue. Observed molecular weight by Western-blot: 76kd
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Tested applications
ELISA, WB, IF
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
Exophilin 1 antibody; KIAA0985 antibody; Rabphilin 3A antibody; rabphilin 3A homolog (mouse) antibody; RPH3A antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of RPH3A recombinant protein (Accession Number: NM_014954). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IF: 1:10-1:100
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Validations
COLO 320 cells were subjected to SDS PAGE followed by western blot with Catalog No:114806(RPH3A antibody) at dilution of 1:800
Immunofluorescent analysis of COLO 320 cells using Catalog No:114806(RPH3A Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
RAB3A is a small G protein that is thought to act in exocytosis of neurotransmitters and hormones in synaptic neurotransmission and cell-cell communication. RPH3A (RPH3A), a RAB3A effector, is a neuronal C2 domain tandem containing protein that is involved in the neuronal transmitter process. Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by progressive motor disturbances, cognitive defects and dementia. Level of rabphilin 3A is substantially decreased in synapses of most brain regions in R6/1 transgenic mouse model of HD suggesting a role of RPH3A in impaired synaptic transmission.
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