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Product Name
Human SBDS / Shwachman-Bodian-Diamond syndrome (His Tag) recombinant protein
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Description
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
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Protein name
Ribosome maturation protein SBDS
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Protein short names
CGI-97; AI836084; SHWACHMAN-BODIAN-DIAMOND SYNDROME; SDS; SHWACHMAN-BODIAN-DIAMOND SYNDROME HOMOLOG (HUMAN); RIBOSOME MATURATION PROTEIN SBDS; 4733401P19RIK; PROTEIN 22A3; SHWACHMAN-BODIAN-DIAMOND SYNDROME PROTEIN HOMOLOG; SWDS; SBDS
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Uniprot ID
Q9Y3A5
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Gene Name
SBDS; CGI-97
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human SBDS (Q9Y3A5) (Met1-Glu250) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SBDS consists of 268 amino acids and predicts a molecular mass of 31 KDa. It migrates as an approximately 30-36 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human SBDS / Shwachman-Bodian-Diamond syndrome Protein (His Tag) SDS-PAGE
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