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Product Name
Mouse SBDS / Shwachman-Bodian-Diamond syndrome (His Tag) recombinant protein
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Description
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).
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Protein name
Ribosome maturation protein SBDS
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Protein short names
CGI-97; SDS; SHWACHMAN-BODIAN-DIAMOND SYNDROME HOMOLOG (HUMAN); AI836084; SHWACHMAN-BODIAN-DIAMOND SYNDROME; 4733401P19RIK; RIBOSOME MATURATION PROTEIN SBDS; SWDS; SBDS; PROTEIN 22A3; SHWACHMAN-BODIAN-DIAMOND SYNDROME PROTEIN HOMOLOG
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Uniprot ID
P70122
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Gene Name
Sbds
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse Sbds (NP_075737.1) (Met1-Glu250) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse Sbds consists 268 amino acids and predicts a molecular mass of 31 kDa.
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Purity
> 95 % as determined by SDS-PAGE.
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Validations
Mouse SBDS / Shwachman-Bodian-Diamond syndrome Protein (His Tag) SDS-PAGE
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