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Product Name
Human Flavokinase / RFK (His Tag) recombinant protein
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Description
Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
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Protein name
Riboflavin kinase
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Protein short names
AF031381; RP11-422N19.2; 0610038L10RIK; KOI-4; FLAVOKINASE; ATP:RIBOFLAVIN 5'-PHOSPHOTRANSFERASE; RIFK
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Uniprot ID
Q969G6
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Gene Name
RFK
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human RFK (Q969G6) (Met1-His155) was expressed with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human RFK consists of 170 amino acids and predicts a molecular mass of 19.5 KDa. It migrates as an approximately 20 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Kinase activity untested
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Validations
Human Flavokinase / RFK Protein (His Tag) SDS-PAGE
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