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Product Name
Rhesus IFNAR1 (Fc Tag) recombinant protein
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Description
Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
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Protein name
Interferon alpha/beta receptor 1
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Protein short names
IFNAR1; CD118; IFN-R-1; AVP; IFAR; INFAR; IFNAR; IFNBR; CRF2-1; IFN-ALPHA-REC; IFRC
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Uniprot ID
H9Z8H4
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Gene Name
IFNAR1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the rhesus IFNAR1 (NP_001253442.1) (Met1-Lys437) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Rhesus
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Molecular weight
The recombinant rhesus IFNAR1 comprises 654 amino acids and has a calculated molecular mass of 74.5 KDa.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Cynomolgus IFNAR1 / IFNAR Protein (Fc Tag) SDS-PAGE
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