Anti-IFNAR1 antibody

Anti-IFNAR1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Mouse monoclonal to IFNAR1

FCM

Human IFNAR1

AVP antibody; AVP antibody; CRF2-1 antibody; CRF2-1 antibody; IFN-alpha-REC antibody; IFN-alpha-REC antibody; IFNAR antibody; IFNAR antibody; IFNAR1 antibody; IFNAR1 antibody; IFNBR antibody; IFNBR antibody; IFN-R-1 antibody; IFN-R-1 antibody; IFRC antibody; IFRC antibody; Ifar antibody; Ifrc antibody; CD118 antibody; Ifnar antibody; Infar antibody; AVP antibody; IFRC antibody; IFNAR antibody; IFNBR antibody; IFN-alpha-REC antibody

Mouse IgG1

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IFNAR1 (rh IFNAR1; P17181-1; Met1-Lys436) and conjugated with PE under optimum conditions, the unreacted PE was removed.

Monoclonal

Aqueous solution containing 0.5% BSA and 0.09% sodium azide

This antibody is stable for 12 months from date of receipt when stored at 2℃-8℃. Protected from prolonged exposure to light. Do not freeze !Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

FCM

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

• Yan H, et al. (1996) Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. EMBO J. 15(5): 1064-74.
• Richter MF, et al. (1998) Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. J Biol Chem. 273(38): 24723-9.
• Abramovich C, et al. (1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.