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Mouse IFNAR1 (His Tag) recombinant protein

Cat.#: 500630

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Special Price 532.2 USD

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Product Information

  • Product Name
    Mouse IFNAR1 (His Tag) recombinant protein
  • Documents
  • Description
    Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Can also transduce IFNB signals without the help of IFNAR2, and not activating the Jak-STAT pathway.
  • Protein name
    Interferon alpha/beta receptor 1
  • Protein short names
    IFRC; CRF2-1; IFNBR; IFN-ALPHA-REC; IFNAR; INFAR; AVP; IFAR; CD118; IFN-R-1; IFNAR1
  • Uniprot ID
    P33896
  • Gene Name
    Ifnar1; Ifar; Ifnar
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain of mouse IFNAR1 (NP_034638.2) extracellular domain (Met 1-Thr 429) was expressed, with a polyhistidine tag at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse IFNAR1 consists of 414 amino acids and has a predicted molecular mass of 47 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm IFNAR1 is approximately 55-60 kDa due to glycosylation.
  • Purity
    > 96 % as determined by SDS-PAGE
  • Activity
    Measured by its ability to inhibit mIFNB1 mediated protection of L929 mouse fibroblast cells infected with vesicular stomatitis virus (VSV) to viral lysis.
    The ED50 for this effect is typically 0.2-1μg/mL.
  • Validations

    Mouse IFNAR1 / IFNAR Protein (His Tag) SDS-PAGE

    Mouse IFNAR1 / IFNAR Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"