Rhesus FCN1/FCNA (Fc Tag) recombinant protein

Cat.#: 504431

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Product Information

  • Product Name
    Rhesus FCN1/FCNA (Fc Tag) recombinant protein
  • Documents
  • Description
    Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. The Ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. Three Ficolins have been identified in humans: L-Ficolin, H-Ficolin and M-Ficolin (also referred to as Ficolin-2, -3 and -1, respectively). They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Dysfunction or abnormal expressions of Ficolins may involved in the pathogenesis of human diseases including infectious and inflammatory diseases, autoimmune disease and clinical syndrome of preeclampsia. They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Upon recognition of the infectious agent, the Ficolins act through two distinct routes: initiate the lectin pathway of complement activation through attached serine proteases (MASPs), and a primitive opsonophagocytosis thus limiting the infection and concurrently orchestrating the subsequent adaptive clonal immune response. Ficolin-1 (FCN1) is predominantly expressed in the peripheral blood leukocytes.
  • Protein short names
    RP23-464C2.11; FCN1; FCNA; FICOLIN A; FCNM; FICOLIN 1
  • Uniprot ID
    F7BW36
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the rhesus FCN1 (XP_001098002.1) (Met1-Ala326) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Rhesus
  • Molecular weight
    The recombinant rhesus FCN1 consists of 538 amino acids and predicts a molecular mass of 59.1 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    Rhesus FCN1 / FCNA Protein (Fc Tag)

    Rhesus FCN1 / FCNA Protein (Fc Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"