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Human FCN1/FCNA (His Tag) recombinant protein

Cat.#: 500248

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Product Information

  • Product Name
    Human FCN1/FCNA (His Tag) recombinant protein
  • Documents
  • Description
    Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.
  • Protein name
    Ficolin-1
  • Protein short names
    FCN1; FCNA; RP23-464C2.11; FCNM; FICOLIN 1; FICOLIN A
  • Uniprot ID
    O00602
  • Gene Name
    FCN1; FCNM
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human FCN1 (NP_001994.2) precursor (Met 1-Ala 326) was expressed with a C-terminal polyhistidine tag.
  • Protein Species
    Human
  • Molecular weight
    The secreted recombinant human FCN1 comprises 308 amino acids with a predicted molecular mass of 33.6 kDa as estimated in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Measured by its binding ability in a functional ELISA.
    1. Immobilized FCN1 at 10 μg/ml can bind biotinylated recombinant human Fetuin-A with a linear range of 16-2000 ng/ml.
    2. Immobilized FCN1 at 10 μg/ml can bind biotinylated recombinant mouse Fetuin-A with a linear range of 16-2000 ng/ml.
  • Validations

    Human Ficolin-1 / Ficolin-A / FCN1 Protein (His Tag) SDS-PAGE

    Human Ficolin-1 / Ficolin-A / FCN1 Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"