Anti-FCN1/FCNA antibody

Cat.#: 106136

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Product Information

  • Product Name
    Anti-FCN1/FCNA antibody
  • Documents
  • Description
    Rabbit monoclonal to FCN1/FCNA
  • Tested applications
    IHC-P
  • Species reactivity
    Human FCN1
  • Alternative names
    Fcn1 antibody; FCN1 antibody; Fcna antibody; FCNM antibody; ficolin 1 antibody; ficolin A antibody; RP23-464C2.11 antibody
  • Immunogen
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained from a rabbit immunized with purified, recombinant Human FCN1 (rh FCN1; NP_001994.2; Met1-Ala326).
  • Clonality
    Monoclonal
  • Formulation
    0.2 μm filtered solution in PBS with 5% trehalose
  • Storage instructions
    This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
    Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
  • Applications

    IHC-P: 1-10 μg/mL

  • Validations

    Ficolin-1 / Ficolin-A / FCN1 Antibody, Rabbit MAb, Immunohistochemistry

    Ficolin-1 / Ficolin-A / FCN1 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of human FCN1 in human placenta with rabbit monoclonal antibody (5 μg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to peripheral blood leukocytes.

    Ficolin-1 / Ficolin-A / FCN1 Antibody, Rabbit MAb, Immunohistochemistry

    Ficolin-1 / Ficolin-A / FCN1 Antibody, Rabbit MAb, Immunohistochemistry

    Immunochemical staining of human FCN1 in human spleen (from 2 donors) with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to peripheral blood leukocytes.

  • Background
    Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. The Ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. Three Ficolins have been identified in humans: L-Ficolin, H-Ficolin and M-Ficolin (also referred to as Ficolin-2, -3 and -1, respectively). They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Dysfunction or abnormal expressions of Ficolins may involved in the pathogenesis of human diseases including infectious and inflammatory diseases, autoimmune disease and clinical syndrome of preeclampsia. They are soluble oligomeric defence proteins with lectin-like activity and they are structurally similar to the human collectins, mannan-binding lectin (MBL) and surfactant protein A and D. Upon recognition of the infectious agent, the Ficolins act through two distinct routes: initiate the lectin pathway of complement activation through attached serine proteases (MASPs), and a primitive opsonophagocytosis thus limiting the infection and concurrently orchestrating the subsequent adaptive clonal immune response. Ficolin-1 (FCN1) is predominantly expressed in the peripheral blood leukocytes.
  • References
    • Thiel S. (2007) Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol Immunol. 44(16): 3875-88.
    • Zhang XL, et al. (2008) Ficolins: structure, function and associated diseases. Adv Exp Med Biol. 632: 105-15.
    • Garred P, et al. (2009) MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol. 46(14): 2737-44.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"