REST Polyclonal Antibody

REST Polyclonal Antibody

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• Material Safety Data Sheets (MSDS)

Polyclonal antibody to REST

IF

Human

REST antibody; NRSF antibody; WT6 antibody; XBR antibody; RE1-silencing transcription factor antibody

Rabbit IgG

Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 760-1060 of human REST (NP_001180437.1).

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20℃. Avoid freeze / thaw cycles.

IF 1:50 - 1:200

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions. Negatively regulates the expression of SRRM3 in breast cancer cell lines. Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural specific splicing events (By similarity). Acts as a regulator of osteoblast differentiation (By similarity).