Mouse ALK-6 / BMPR1B (Fc Tag) recombinant protein

Mouse ALK-6 / BMPR1B (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.

Receptor protein serine/threonine kinase

ACVRLK6; CDW293; BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1BSERINE/THREONINE RECEPTOR KINASE; CFK-43A; ACTIVIN RECEPTOR-LIKE KINASE 6; BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B; ALK6; ALK-6; AI385617; SERINE/THREONINE-PROTEIN KINASE RECEPTOR R6; AV355320; BMP TYPE-1B RECEPTOR; BMPR-1B; SKR6; BMPR-IB

P36898

Bmpr1b; mCG_122207

Human Cells

A DNA sequence encoding the mouse Bmpr1b (NP_031586.1) (Lys14-Lys126) was expressed with the Fc region of human IgG1 at the C-terminus.

Mouse

The recombinant mouse Bmpr1b consists 351 amino acids and predicts a molecular mass of 39.4 kDa.

> (88.3+9.9) % as determined by SDS-PAGE.