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Product Name
Human ALK-6 / BMPR1B (His & GST Tag) recombinant protein
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Description
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity). {UniProtKB:P36898}.
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Protein name
Bone morphogenetic protein receptor type-1B
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Uniprot ID
O00238
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Gene Name
BMPR1B
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human ALK6 (NP_001194.1) cytoplasmic domain (Arg 149-Leu 502) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ALK6 (149-502)/GST chimera consists of 591 amino acids and has a calculated molecular mass of 68.3 KDa. It migrates as an approximately 55 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Activity
Kinase activity untested
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Validations
Human BMPR1B / ALK-6 (149-502) Protein (His & GST Tag) SDS-PAGE
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