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Product Name
Anti-ALK-6 / BMPR1B antibody
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Description
Rabbit polyclonal to ALK-6 / BMPR1B
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Tested applications
ELISA, WB
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Species reactivity
Human ALK-6 / BMPR1B
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Alternative names
Alk6 antibody; SKR6 antibody; ALK-6 antibody; Acvrlk6 antibody; BMPR-1B antibody; BMPR-IB antibody; CFK-43a antibody; AI385617 antibody; AV355320 antibody; ALK6 antibody; ALK-6 antibody; CDw293 antibody; activin receptor-like kinase 6 antibody; activin receptor-like kinase 6 antibody; Acvrlk6 antibody; AI385617 antibody; Alk6 antibody; ALK6 antibody; ALK-6 antibody; ALK-6 antibody; AV355320 antibody; BMP type-1B receptor antibody; BMP type-1B receptor antibody; BMPR-1B antibody; BMPR-1B antibody; BMPR-IB antibody; bone morphogenetic protein receptor type-1B antibody; bone morphogenetic protein receptor type-1Bserine/threonine receptor kinase antibody; CDw293 antibody; CFK-43a antibody; serine/threonine-protein kinase receptor R6 antibody; SKR6 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with purified, recombinant Human ALK-6 / BMPR1B (rh ALK-6 / BMPR1B; NP_001194.1; Arg149-Leu502). ALK-6 / BMPR1B specific IgG was purified by Human ALK-6 / BMPR1B affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
WB: 10-30 μg/ml
ELISA: 0.1-0.2 μg/ml
This antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Human ALK-6 / BMPR1B. The detection limit for Human ALK-6 / BMPR1B is approximately < 0.039 ng/well.
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Validations
ALK-6 / BMPR1B Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Background
BMPR1B(bone morphogenetic protein receptor, type IB), also known as ALK6, is a a member of the bone morphogenetic protein (BMP) receptor family. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMPR1B is the major transducer of signals in precartilaginous condensations as demonstrated in experiments using constitutively active BMPR1B receptors. BMPR1B is a more effective trasducer of GDF5 than BMPR1A. Unlike BMPR1A null mice, which die at an early embryonic stage, BMPR1B null mice are viable.
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References
- Ide H, et al. (1998) Assignment of the BMPR1A and BMPR1B genes to human chromosome 10q22.3 and 4q23--q24 byin situ hybridization and radiation hybrid map ping. Cytogenet. Cell Genet. 81(3-4): 285-6.
- Mishina Y, et al. (2004) Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling. J Biol Chem. 279(26): 27560-6.
- Yoon BS, et al. (2005) Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo. Proc Natl Acad Sci. 102(14): 5062-7.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"